Related Projects

Bupivacaine Injection Treatment of Strabismus (PI: Alan B Scott)

Existing treatments for strabismus rely on compensatory impairment of EOMs; we are harnessing the hypertrophic consequences of bupivacaine myotoxicity to directly strengthen them. Development of bupivacaine for controlled muscle strengthening would provide a unique and powerful tool for strabismus management, and would likely have value for treatment of muscle disorders beyond ophthalmology (Paper PDF, 0.3MB).

EOM Forces & Neural Control of a Complex Oculomotor Plant

Motor control issues raised by conflicts between classical motoneuron studies and physiologic EOM force measurements • Forces in convergence. (InfoIcons illustrate paradoxical reduction of EOM force despite increased motoneuron firing in convergence, and the pulse-slide-step saccadic force profile).

Extraocular Biomechanics

Biomechanics of the eye, surrounding tissues and innervations • Computer model for researchers and clinicians

Extraocular Tissue Architecture

3-D architecture of the extraocular space, distinguishing striated muscle, smooth muscle, collagen, elastin, and other tissues. Techniques include MRI, histochemistry and 3D reconstruction from distorted slices using hierarchical warping and intrinsic fiducials

Direction Perception & Sensorimotor Adaptation

Egocentric direction of visual objects around the time of normal and gain-adapted saccades • Adaptation & displacement detection • Saccadic Gain Plasticity, in humans and monkeys, reflected in eye position and muscle force changes

LabOS Data Acquisition & Control for Biomedical Experiments - A new software system providing both a rich user interface and deterministic closed-loop control at biological rates of experiments specified by complex protocols.

Orbit™ 2: A Biomechanical Modeling Environment for Eye Movement & Orbital Reconstruction - Development of a Biomechanical Modeling Environment that is modern, platform-independent, and object-oriented, with a layered, graphical user interface.